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Martin JL, Baxter RC

[9] Its also prudent to be cautious or avoid NAD+ injections if you have a serious uncontrolled medical condition (for example, end-stage liver or kidney disease or severe heart disease), unless your physician specifically determines its safe

Selenium excretion is reduced during pregnancy

Research protocols typically administer 5-amino-1mq on an empty stomach to avoid food-mediated absorption interference, though no published studies have directly tested fed versus fasted states for this specific peptide